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Dr. Claudia Schmauss's curriculum vitae
 

CURRICULUM VITAE

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Name:
Birthplace:
Citizenship:      		Claudia Schmauss
Berlin, Germany
Germany
Permanent resident of the United States

ACADEMIC TRAINING:

1974-1980: Humboldt University School of Medicine
Berlin, Germany

1979: M.A. (Physiology)
Humboldt University, Berlin

1980: M.D.
Humboldt University, Berlin
(ECFMG Certification Number (USA): 355-354-0)


TRAINEESHIP:

Postdoctoral training:

1981-1982: Postdoctoral Fellow in Neuropharmacology
Mayo Clinic, Rochester, MN

1987-1991: Associate Research Scientist in Molecular Neurobiology
Yale University School of Medicine
Section of Molecular Neurobiology (HHMI)
New Haven, CT

Resident training:

1983-1987: Resident in Psychiatry
Max Planck Institute for Psychiatry
Munich, Germany.

1987: German Specialty Board Certification in Psychiatry

PROFESSIONAL ORGANIZATIONS AND SOCIETIES:

Society for Neuroscience (USA), member
American Association for the Advancement of Science, member

ACADEMIC APPOINTMENTS:

1991-1996: Assistant Professor
Department of Psychiatry and Brookdale Center for Molecular Biology
Mount Sinai School of Medicine, New York, NY

1997-1998: Associate Professor
Department of Psychiatry and Brookdale Center for Molecular and Developmental Biology
Mount Sinai School of Medicine, New York, NY

1998-present: Associate Professor
Department of Psychiatry, Columbia University College of
    Physicians & Surgeons
Research Scientist V
New York State Psychiatric Institute, New York, NY

HONORS:

1987: Otto Hahn Research Award sponsored by the Max Planck Society, Germany
1996: Irma T. Hirschl Career Scientist Award
2001: Essel Investigator (NARSAD)

TEACHING:

Lecturer:
1991-1998: Lecturer in the Biochemistry Core I course, CUNY & Mount Sinai Graduate School

1991-1998: Lecturer in the Neuroscience Course (Psychiatry, PGYII), Mount Sinai School of Medicine

Preceptor of Predoctoral Trainees:

1996-1999: Mi-Young Jung, PhD student in Neurobiology, Mount Sinai Graduate School, Title of thesis: "Molecular phenotypes of mice deficient for dopamine D2 and D3 receptors examined during postnatal development"
Graduated in August 1999

1998-2002: Ilona Gurevich, PhD student in Molecular Biology, Mount Sinai Graduate School, Title of the thesis: "Serotonin 2C receptor pre-mRNA processing in human and mouse neocortex: potential mechanisms of regulation"
Graduated in May 2002

Mentor of Postdoctoral Fellows:

1994-1997: Boris Skryabin, MD, PhD
2000-present: Sara B. Glickstein, PhD
2000-present: Mella Adlersberg, PhD
2002-present: Ilona Gurevich, PhD

Sponsor of Undergraduate Research Trainees:

1996: Julie H. Yoon (Wellesley College; supported by an NSF-REU supplement)
1996: Nicholas Bianchi (Carnegie Mellon Univ, Sigma Xi Stipend)
1997: Julia Kirsch (Technical University, Berlin)
2002-present: Michael Englander, B. A. (post Bachelor pre-med student, Columbia University)


PUBLICATIONS

A. ORIGINAL PEER-REVIEWED REPORTS

  1. Schmauss, C., Berthot, W. & Siegmund, H. (1981).  Effekte der Ablatio des auditorischen Cortex auf die audio-visuelle targeting Reaktion bei Katzen.  Erg. Exp. Forsch. 4:72.

  2. Schmauss, C. (1981).  Neue Ergebnisse der experimentellen Schmerzforschung. Sensorische Modulation der nozizeptiven Information.  Dtsch. Ges. Wesen 37: 698-704.

  3. Kulawik, H. & Schmauss, C. (1982).  Psychotherapie. Methoden. Kombinationen. Zwischenbilanz und Neubesinnung.  Psychiat. Neurol. med. Psychol. 34: 641-646.

  4. Yaksh, T. L., Schmauss, C., Micevich, P. E., Abay, E. O. & Go, V. L. V.(1982).  Pharmacological studies on the application, disposition and release of neurotensin in the spinal cord.  Ann. New York Acad. Sci. 400: 228-243.

  5. Schmauss, C., Doherty, C. & Yaksh, T. L. (1983).  The analgesic effect of the intrathecally administered partial opiate agonist nalbuphine hydrochloride.  Eur. J. Pharmacol. 86: 1-7.

  6. Schmauss, C., Hammond, D. L., Ochi, J. & Yaksh, T. L. (1983).  Pharmacological antagonism of the antinociceptive effect of serotonin in the rat spinal cord.  Eur. J. Pharmacol. 90: 349-357.

  7. Schmauss, C., Yaksh, T. L., Shimohigashi, Y., Hardy, G., Jenssen, T. & Rodbard, D. (1983).  Differential association of spinal mu, delta, and kappa opioid receptors with cutaneous thermal and chemical visceral nociceptive stimuli in the rat.  Life Sci. 33, Suppl. I: 653-656.

  8. Schmauss, C. & Yaksh, T. L. (1983).  In vivo studies on spinal opioid receptor systems mediating antinociception. II. Pharmacological profile suggesting an differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.  J. Pharmacol. Exp. Ther. 228: 1-12.

  9. Millan, M. J., Schmauss, C. Millan, M. & Herz, A. (1984).  Vassopressin and oxitocin in the rat spinal cord: Analysis of their role in nociception.  Brain Res. 309: 384-388.

  10. Schmauss, C., Shimohigashi, Y., Jenssen, T., Rodbard, D. & Yaksh, T. L. (1984).  In vivo studies on spinal opioid receptor systems mediating antinociception. III. Analgesic effects of enkephalin dimers as measured by cutaneous thermal and visceral chemical evoked responses in the rat.  Brain Res. 377: 209-215.

  11. Schmauss, C., Apelt, S. & Emrich, H. M. (1987).  Benzodiazepine withdrawal in high- and low-dose dependent psychiatric inpatients.  Brain Res. Bull. 19: 393-400.

  12. Schmauss, C. & Krieg, C. J. (1987).  Enlargement of cerebrospinal fluid spaces in long-term benzodiazepine abusers.  Psychol. Med. 17: 869-873.

  13. Schmauss, C. & Herz, A. (1987).  Spinal dynorphin 1-17 differentially modulates morphine analgesia in morphine-naive and morphine-tolerant rats.  Eur. J. Pharmacol. 135: 429-431.

  14. Schmauss, C. (1987).  Spinal kappa-opioid receptor mediated antinociception is stimulus-specific.  Eur. J. Pharmacol. 137: 197-205.

  15. Schmauss, C., Yassouridis, A. & Emrich, H. M. (1987).  The effects of the partial opiate agonist buprenorphine on acute psychotic symptoms in patients suffering from schizophrenia.  Am. J. Psychiat. 144: 1340-1341.

  16. Schmauss, C., Apelt, S. & Emrich, H. M. (1988).  Liking and seeking potentials of alprazolam and diazepam in bromazepam dependent patients.  Am. J. Psychiat. 145: 128.

  17. Schmauss, C., Apelt, S. & Emrich, H. M. (1989).  Preference of alprazolam over diazepam.  Am. J. Psychiat. 145: 408.

  18. Schmauss, C., McAllister, G., Ohosone, Y., Hardin, J. A. & Lerner, M. R. (1989).  A comparison of the snRNP-associated Sm-autoantigens human N, rat N and human B/ B'.  Nucl. Acids. Res. 17: 1733-1744.

  19. Schmauss, C. & Lerner, M. R. (1990).  The closely related snRNP polypeptides N and B/ B' are distinguishable by antibodies as well as by differences in their mRNA and gene structures.  J. Biol. Chem. 265: 10733-10739.

  20. Schmauss, C., Brines, M. L.& Lerner, M. R. (1992).  The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons.  J. Biol. Chem. 267: 8521-8529.

  21. Griffith, A., Schmauss, C. & Craft, J. (1992).  The Sm B protein is highly conserved between species and its murine gene contains a nonfunctional alternative 3' splice site.  Gene 114: 195-201.

  22. Schmauss, C., Haroutunian, V, Davis, K. L.& Davidson, M. (1993).  Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices in patients with chronic schizophrenia.  Proc. Natl. Acad. Sci. USA 90, 8942-8946.

  23. Potenza, M. N., Graminski, G. F., Schmauss, C. & Lerner, M. R. (1994).  Functional expression and characterization of human D2 and D3 dopamine receptors.  J. Neurosci. 14, 1463-1476.

  24. Liu, K., Bergson, C., Levenson, R. & Schmauss, C. (1994).  On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain.  J. Biol. Chem. 269, 29220-29226.

  25. Howe, J. R., Skryabin, B. V. Belcher, S. M., Zerillo, C. A. & Schmauss, C. (1995).  The responsiveness of a tetracycline-sensitive expression system differs in different cell lines.  J. Biol. Chem. 270, 14168-14174.

  26. Schmauss, C. (1996).  Enhanced cleavage of an atypical intron of dopamine D3-receptor pre-mRNA in chronic schizophrenia.  J. Neurosci. 16: 7902-7909.

  27. Skryabin, B. V. & Schmauss, C. (1997).  Enhanced selection for homologous-recombinant embryonic stem cell clones with a neomycine phosphotransferase gene in antisense orientation.  Transgenic Res. 6: 27-35.

  28. Nimchinsky, E. A., Hof, P. R., Janssen, W. G. M., Morrison, J. H. & Schmauss, C. (1997).  Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells.  J. Biol. Chem. 272: 29229-29237.

  29. Jung, M.-Y., Skryabin, B. V., Arai, M., Abbondanzo, S., Fu, D., Robakis, N. K., Brosius, J., Polites, H. G., Pintar, J. E. & Schmauss, C. (1999).  Potentiation of the D2-mutant motor phenotype in mice lacking dopamine D2 and D3 receptors.  Neuroscience 91: 911-924.

  30. Jung, M. J. & Schmauss (1999).  Decreased c-fos responses to dopamine D1-receptor stimulation in mice deficient for D3 receptors.  J. Biol. Chem. 274: 29406-29412.

  31. Jung, M.-Y., Hof, P. R., and Schmauss, C. (2000).  The targeted disruption of the dopamine D2 and D3 receptor genes leads to different alterations in the expression of striatal calbindin-D28K.  Neuroscience 97: 495-504.

  32. Schmauss, C. (2000).  A single dose of methamphetamine leads to a long-term reversal of the blunted neocortical dopamine D1-receptor mediated c-fos responses in mice deficient for D2 and D3 receptors.  J. Biol. Chem 275: 38944-38948.

  33. Schmitz, Y., Lee, J., Schmauss, C., Gonon, F., and Sulzer, D. (2001).  Amphetamine distorts synaptic dopamine overflow: effects on vesicular stores, D2 autoreceptors, and uptake.  J. Neurosci. 21: 5916-5924.

  34. Gurevich, I., Tamir, H., Arango, V., Dwork, A. J., Mann, J. J., and Schmauss, C. (2002).  Altered editing of 5-HT2C pre-mRNA in the prefrontal cortex of depressed suicide victims.  Neuron 34: 349-356.

  35. Glickstein, S. B., Hof, P. R., and Schmauss, C. (2002).  Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits.  J. Neurosci. 22(13): 5619-5629.

  36. Schmitz Y., Schmauss C., Sulzer D. (2002)  Altered dopamine release and uptake kinetics in mice lacking D2 receptors.  J. Neurosci. 22(18): 8002-8009.

  37. Gurevich, I., Englander, M. T., Adlersberg, M., Siegal, N. B., and Schmauss, C. (2002).  Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission.  J. Neurosci. 22 (24): 10529-10532.

  38. Glickstein, S.B. and Schmauss, C. (2004).  Focused motor stereotypies do not require enhanced activation of neurons in striosomes.  J. Comp. Neurol. 469: 227-238.

  39. Bamford, N.S., Zhang, H., Schmitz, Y., Wu, N.-P., Cepeda, C., Levine, M.S., Schmauss, C., Zakharenko, S.S., Zablow, L., and Sulzer, D. (2004).  Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.  Neuron 42: 653-663.

  40. Adlersberg, M., Hsiung, S.-c., Liu, K.-p., Glickstein, S.B., Tamir, H. and Schmauss, C (2004).  Regulation of dopamine D1 receptor activation in vivo by protein phosphatase 2B (calcineurin).  J. Neurochem, 90: 865-873.

  41. Glickstein, S.B., DeSteno, D.A., Hof, P.R. and Schmauss, C. (2004).  Mice lacking dopamine D2 and D3 receptors exhibit different differential activation of prefrontal cortical neurons during tasks requiring attention.  Cerebral Cortex, in press.

  42. Englander, M.T., Dulawa, Bhansali, P., and Schmauss, C. (2004).  How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing.  J. Neurosci., in press.

B. CHAPTERS AND BOOKS

  1. Schmauss, C., Apelt, S., Pirke, K. M. & Emrich, H. M. (1986).  The effects of the partial opioid agonist buprenorphine on acute psychotic symptoms and plasma prolactin levels of schizophrenic inpatients.  In Shagass, C., Josiassen, R. C., Bridger, W. H., Weiss, K. J., Stoff, D. & Simpson, G. M. [Eds].  Dev. Psychiat. Vol. 7, pp 305-308. (chapter)

  2. Schmauss, C. & Emrich, H. M. (1987).  The effects of opioids on behavior.  Possible role in psychotogenesis.  In: Nemeroff, C. B. & Loosen, P. T. [Eds].  Handbook of Psychoneuroendocrinology.  The Guilford Press, New York, pp. 417-428. (chapter)

  3. Schmauss, C. & Emrich, H. M. (1988).  Narcotic antagonist and opioid treatment in psychiatry.  In: Rogers, R. J & Cooper, S. J. [Eds]. Endorphins, Opiates and Behavioral Processes. Whiley Ltd., London, pp. 327-351. (chapter)

  4. Schmauss, C., Pirke, K. M., Bremer, D., Weber, M. & Emrich, H. M. (1989).  Luteinizing hormone and prolactin response to buprenorphine in depression and schizophrenia.  In: Lerer, B. & Gershon, S. [Eds] New Directions in Affective Disorders. Springer. New York, pp. 276-279. (chapter)

  5. Emrich, H. M. & Schmauss, C. (1991).  Psychiatric aspects of opioid research.  In: Almeida, O. F. X. & Shippenberg, T. S. [Eds]. Neurobiology of Opioids. Springer-Verlag, pp. 363-367. (chapter)

  6. Schmauss, C. (2002).  Dopamine Receptors / Transporters.  In: Wiley Encyclopedia of Molecular Medicine.  John Wiley & Sons, Inc. New York, New York, Vol 2, pp. 1095-1098 (chapter)

C. REVIEWS AND EDITORIALS

  1. Schmauss, C. & Emrich, H. M. (1985).  The relevance of dopamine to the effects evoked by opiates.  A re-evaluation of the dopamine hypothesis of schizophrenia with special consideration of the proposed involvement of endogenous opioids.  Biol. Psychiat. 20: 1211-1231.  (review).

  2. Schmauss, C. (2000).  Dopamine receptors: Novel insights from biochemical and genetic studies. The Neuroscientist 6(2): 125-136. (review)

  3. Glickstein, S. B. & Schmauss, C. (2001).  Dopamine receptor functions: Lessons from knockout mice.  Pharmacol. & Therapeut., 91(1): 63-83. (review)

  4. Schmauss, C., Glickstein, S. B., Adlersberg, M., Hsiung, S.-C., and Tamir, H. (2002).  A single dose of methamphetamine rescues the blunted dopamine D1 receptor activity in the neocortex of D2-and D3-receptor knockout mice.  In: Cellular and Molecular Mechanisms of Drugs of Abuse II: Cocaine, GHB, Ibogaine, and Substituted Amphetamines.  Syed F. Ali [Ed]. Ann. New York Acad. Sci. 965: 21-27.

  5. Schmauss, C. & Howe, J. R. (2002).  RNA editing of neurotransmitter receptors in the mammalian brain.  Science's STKE(2002); http://www.stke.org/cgi/content/full/OC_ sigtrans;2002/133/pe26  (Review/ Perspective)

  6. Schmauss, C. (2003).  Serotonin 2C receptors: Suicide, serotonin, and runaway RNA editing.  The Neuroscientist 9: 237-242 (review).

  7. Glickstein, S.B. & Schmauss, C. (2004).  Effect of methamphetamine on cognition and repetitive motor behavior of mice deficient for dopamine D2 and D3 receptors.  In: Current Status of Dependence/Abuse: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity.  Syed F. Ali & Toshitaka Nabeshima [Eds] Ann. New York Acad. Sci. 1025: 110-118.

  8. Schmauss, C. (2004).  Regulation of serotonin 2C receptor pre-mRNA editing by serotonin.  Int. Rev. Neurobiol. 63: in press

D. ABSTRACTS (since 1998 only)

  1. Jung, M.-Y, & Schmauss, C. (1998).  Altered induction of c-fos expression following dopamine D1-receptor stimulation in mice lacking D2, D3, and D2/D3 receptors.  28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA.

  2. Jung, M.-Y., Hof, P.R., & Schmauss, C. (1999).  Expression of calbindin-D28K immunoreactivity in the dorsal striatum of mice lacking dopamine D2, D3, and D2/D3 receptors.  29th Annual Meeting of the Society for Neuroscience, Miami, FL.

  3. Gurevich, I., Arango, V., Dwork, A.J., Mann, J.J., & Schmauss, C.(1999).  Altered editing of the 5-HT2C pre-mRNA in the prefrontal cortex of suicide victims with a history of major depression.  29th Annual Meeting of the Society for Neuroscience, Miami, FL.

  4. Schmitz, Y., Schmauss, C., & Sulzer, D. (1999).  Striatal dopamine (DA) release in response to different stimulation pattern and its control by D2 autoreceptors. 29th Annual Meeting of the Society for Neuroscience, Miami, FL.

  5. Schmauss, C. (2000).  A single dose of amphetamine leads to a long-term reversal of the blunted neocortical dopamine D1-receptor mediated c-fos responses in mice deficient for D2 and D3 receptors.  30th Annual Meeting of the Society for Neuroscience, New Orleans, LA.

  6. Glickstein, S.B., Adlersberg, M., Tamir, H., & Schmauss, C. (2000).  Decreased agonist-promoted dopamine D1-receptor activity in the neocortex of mice deficient for D2 and D3 receptors.  39st Annual Meeting of the American College for Neuropsychopharmacology, San Juan, PR

  7. Hsiung, S.C., Adlersberg, M., Schmauss, C., & Tamir (2001).  Decreased dopamine D1-receptor-activated binding of [35S]GTPgS in the neocortex of mice deficient for D2 receptors.  31st Annual Meeting of the Society for Neuroscience, San Diego, CA.

  8. Glickstein, S.B. & Schmauss, C. (2001).  c-fos mRNA and protein responses to dopamine D1-agonist stimulation in the prefrontal cortex of mice deficient for D2 and D3 receptors.  31st Annual Meeting of the Society for Neuroscience, San Diego, CA.

  9. Englander, M.T., and Schmauss, C. (2003).  Cross-talk between serotonergic and dopaminergic neurotransmission at the level of pre-mRNA processing.  33rd Annual Meeting of the Society for Neuroscience, New Orleans, LA.

  10. Glickstein, S.B., and Schmauss, C. (2003).  Focused motor stereotypies do not require enhanced activation of neurons in striosomes.  33rd Annual Meeting of the Society for Neuroscience, New Orleans, LA.

  11. Englander, M.T., Gurevich, I., and Schmauss, C. (2004).  5-HT2C pre-mRNA editing in depression and schizophrenia: What alters editing site preferences?  EPHAR 2004, Serotonin Satellite Meeting, Porto, Portugal.

  12. Glickstein, S.B., DeSteno, D.A., and Schmauss, C. (2004).  Mice lacking dopamine D2 and D3 receptors exhibit differential activation of prefrontal cortical neurons during tasks requiring attention.  34th Annual Meeting of the Society for Neuroscience, San Diego, CA
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